We observed that all patients (N=72) had an elevated MPV, ranging from 9.1 to 13,7 and a mean of 11,57fL. They were evaluated by a hemogram with the MPV and answered to a questionary about risk factors to coronary disease. The patients included were those who would be submitted to procedures like coronariography, angioplasty and myocardial bypass. The aim of this study was to evaluate the MPV in Coronary diseases patients and correlate it with risk factors to these diseases. The reasons for this are not well known, but may be due to platelet aggregation or consumption. Many studies found association between the MPV and the ACS or the occurrence of Acute Myocardial Infarction (AMI). It is believed that the mean platelet size, evaluated by the mean platelet volume (MPV), is a sensitive indicator of platelet reactivity and thrombogenicity potential. ISBN 9780683307511.Platelets have a predominant role in the pathogenesis of Acute Coronary Syndromes (ACS). "Bernard-Soulier Syndrome Workup: Approach Considerations".
^ Liu S, Ren J, Han G, Wang G, Gu G, Xia Q, Li J (October 2012).Archives of Pathology & Laboratory Medicine. "Increased mean platelet volume in patients with acute coronary syndromes". ^ Lippi G, Filippozzi L, Salvagno GL, Montagnana M, Franchini M, Guidi GC, Targher G (September 2009).Arteriosclerosis, Thrombosis, and Vascular Biology. ^ "Mean Platelet Volume May Represent a Predictive Parameter for Overall Vascular Mortality and Ischemic Heart Disease".Familial platelet disorder with predisposition to AML.Congenital amegakaryocytic thrombocytopenia.Inherited thrombocytopenia with normal MPV Administration of erythropoietin / thrombopoietin.Acquired Immunodeficiency Syndrome ( AIDS).2 Inherited thrombocytopenia with normal MPVĬonditions associated with altered MPV Decreased MPV.1 Conditions associated with altered MPV.A typical range of platelet volumes is 9.4–12.3 fL ( femtolitre), equivalent to spheres 2.65 to 2.9 µm in diameter. Sample for MPV testing is obtained in a Lavender-Top EDTA tube.
In addition, low MPV may correlate with abnormally small platelet size, sometimes a symptom of a spectrum referred to as Wiskott–Aldrich syndrome (WAS), caused by a genetic mutation of the WAS gene. A high MPV is also a bad prognostic marker in patients with sepsis or septic shock. A low MPV may indicate inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis. Ībnormally low MPV values may correlate with thrombocytopenia when it is due to impaired production of megakaryocytes in the bone marrow, such as in aplastic anemia. It may also be related to pre-eclampsia and recovery from transient hypoplasia. This may be seen in immune thrombocytopenic purpura (ITP), myeloproliferative diseases and Bernard–Soulier syndrome. MPV may be higher when there is destruction of platelets. Īn increased mean platelet volume (MPV) increases the risk to suffer a heart disease Since the average platelet size is larger when the body is producing increased numbers of platelets, the MPV test results can be used to make inferences about platelet production in bone marrow or platelet destruction problems. Mean platelet volume ( MPV) is a machine-calculated measurement of the average size of platelets found in blood and is typically included in blood tests as part of the CBC. Can be used to make inferences about platelet production in bone marrow or platelet destruction problems
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